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Allergic reactions are in fact quite rare, estimated to have an incidence of 1 perinjections. Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA. Procaine can also cause allergic reactions causing individuals to have problems with breathing, rashes, and swelling.

Procaine may also induce weakening of the myocardium leading to cardiac arrest. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Studies on animals have shown the use of procaine led to the increase of dopamine and serotonin levels in the brain. The depression causes the nervous system to become hypersensitive, producing restlessness and shaking, leading to minor to severe convulsions. Application of procaine leads to the depression of neuronal activity. Procaine is an occasional additive in illicit street drugs, such as cocaine. Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid PABAwhich is then excreted by the kidneys into the urine. Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required. Like other local anesthetics such as mepivacaineand prilocaineprocaine is a vasodilator, thus is often coadministered with epinephrine for the purpose of vasoconstriction. Procaine is used less frequently today, since more effective and hypoallergenic alternatives such as lidocaine Xylocaine exist. Prior to the discovery of amylocaine and procaine, cocaine was a commonly used local anesthetic. It was introduced into medical use by surgeon Heinrich Braun. Procaine was first synthesized in shortly after amylocaine. It acts mainly as a sodium channel blocker. Owing to the ubiquity of the trade name Novocainin some regions, procaine is referred to generically as novocaine. It is used primarily to reduce the pain of intramuscular injection of penicillinand it is also used in dentistry. Procaine is a local anesthetic drug of the amino ester group.

Making crack with levamisole hydrochloride